MovDisordV3, Main, Exploration, bibRecord, 000E33

Comparison of dysphagia before and after deep brain stimulation in Parkinson's disease.

Identifieur interne : 000E33 ( Main/Exploration ); précédent : 000E32; suivant : 000E34

Comparison of dysphagia before and after deep brain stimulation in Parkinson's disease.

Auteurs : Alice K. Silbergleit [États-Unis] ; Peter Lewitt ; Fred Junn ; Lonni R. Schultz ; Denise Collins ; Tausha Beardsley ; Meghan Hubert ; Richard Trosch ; Jason M. Schwalb

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.

RBID : pubmed:23115021

English descriptors

KwdEn :
- Adult, Aged, Deep Brain Stimulation (methods), Deglutition, Deglutition Disorders (etiology), Deglutition Disorders (physiopathology), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Self Concept, Subthalamic Nucleus (physiopathology), Treatment Outcome.
MESH :
- complications : Parkinson Disease.
- etiology : Deglutition Disorders.
- methods : Deep Brain Stimulation.
- physiopathology : Deglutition Disorders, Parkinson Disease, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Deglutition, Female, Humans, Male, Middle Aged, Self Concept, Treatment Outcome.

Abstract

Although dysphagia is a common problem for many Parkinson's disease (PD) patients, the effect of deep brain stimulation (DBS) on swallowing is unclear. Fourteen subjects with advanced PD underwent videofluorographic swallowing studies prior to bilateral DBS of the subthalamic nucleus (STN) and at 3 and 12 months postprocedure. They were tested under several stimulation and medication conditions. Subjects completed the Dysphagia Handicap Index at each time. There was a strong trend toward improved swallowing response for solid intake in the medication-free condition with the stimulator on compared with the stimulator off (P = .0107). Also, there was a trend toward improved oral preparation of thin liquids (P = .0368) in the medication-free condition when the stimulator was on versus off 12 months later. The remaining swallowing parameters showed no change or worsening of swallowing function regardless of stimulator or medication status. Results of the Dysphagia Handicap Index revealed significant improvement in subject self-perception of swallowing 3 and 12 months following the procedure compared with baseline on the functional subscale (P = .020 and P = .010, respectively), the emotional subscale (P = .013 and P = .003, respectively), and the total score (P = .025 and P = .003, respectively). These data suggest that bilateral STN-DBS does not substantively impair swallowing in PD. In addition, it may improve motor sequencing of the oropharyngeal swallow for solid consistencies (which are known to provide increased sensory feedback to assist motor planning of the oropharyngeal swallow). Subjects with advanced PD who are undergoing DBS may perceive significant improvement in swallowing ability despite the lack of objective improvements in swallowing function.

DOI: 10.1002/mds.25259
PubMed: 23115021

Affiliations:

États-Unis

Le document en format XML

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<author><name sortKey="Schultz, Lonni R" sort="Schultz, Lonni R" uniqKey="Schultz L" first="Lonni R" last="Schultz">Lonni R. Schultz</name>
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<author><name sortKey="Collins, Denise" sort="Collins, Denise" uniqKey="Collins D" first="Denise" last="Collins">Denise Collins</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of dysphagia before and after deep brain stimulation in Parkinson's disease.</title>
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<author><name sortKey="Lewitt, Peter" sort="Lewitt, Peter" uniqKey="Lewitt P" first="Peter" last="Lewitt">Peter Lewitt</name>
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<author><name sortKey="Schultz, Lonni R" sort="Schultz, Lonni R" uniqKey="Schultz L" first="Lonni R" last="Schultz">Lonni R. Schultz</name>
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<author><name sortKey="Collins, Denise" sort="Collins, Denise" uniqKey="Collins D" first="Denise" last="Collins">Denise Collins</name>
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<author><name sortKey="Beardsley, Tausha" sort="Beardsley, Tausha" uniqKey="Beardsley T" first="Tausha" last="Beardsley">Tausha Beardsley</name>
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<author><name sortKey="Hubert, Meghan" sort="Hubert, Meghan" uniqKey="Hubert M" first="Meghan" last="Hubert">Meghan Hubert</name>
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<author><name sortKey="Trosch, Richard" sort="Trosch, Richard" uniqKey="Trosch R" first="Richard" last="Trosch">Richard Trosch</name>
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<author><name sortKey="Schwalb, Jason M" sort="Schwalb, Jason M" uniqKey="Schwalb J" first="Jason M" last="Schwalb">Jason M. Schwalb</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Deglutition Disorders (etiology)</term>
<term>Deglutition Disorders (physiopathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Self Concept</term>
<term>Subthalamic Nucleus (physiopathology)</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Deglutition Disorders</term>
<term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Deglutition</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">Although dysphagia is a common problem for many Parkinson's disease (PD) patients, the effect of deep brain stimulation (DBS) on swallowing is unclear. Fourteen subjects with advanced PD underwent videofluorographic swallowing studies prior to bilateral DBS of the subthalamic nucleus (STN) and at 3 and 12 months postprocedure. They were tested under several stimulation and medication conditions. Subjects completed the Dysphagia Handicap Index at each time. There was a strong trend toward improved swallowing response for solid intake in the medication-free condition with the stimulator on compared with the stimulator off (P = .0107). Also, there was a trend toward improved oral preparation of thin liquids (P = .0368) in the medication-free condition when the stimulator was on versus off 12 months later. The remaining swallowing parameters showed no change or worsening of swallowing function regardless of stimulator or medication status. Results of the Dysphagia Handicap Index revealed significant improvement in subject self-perception of swallowing 3 and 12 months following the procedure compared with baseline on the functional subscale (P = .020 and P = .010, respectively), the emotional subscale (P = .013 and P = .003, respectively), and the total score (P = .025 and P = .003, respectively). These data suggest that bilateral STN-DBS does not substantively impair swallowing in PD. In addition, it may improve motor sequencing of the oropharyngeal swallow for solid consistencies (which are known to provide increased sensory feedback to assist motor planning of the oropharyngeal swallow). Subjects with advanced PD who are undergoing DBS may perceive significant improvement in swallowing ability despite the lack of objective improvements in swallowing function.</div>
</front>
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<tree><noCountry><name sortKey="Beardsley, Tausha" sort="Beardsley, Tausha" uniqKey="Beardsley T" first="Tausha" last="Beardsley">Tausha Beardsley</name>
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<name sortKey="Hubert, Meghan" sort="Hubert, Meghan" uniqKey="Hubert M" first="Meghan" last="Hubert">Meghan Hubert</name>
<name sortKey="Junn, Fred" sort="Junn, Fred" uniqKey="Junn F" first="Fred" last="Junn">Fred Junn</name>
<name sortKey="Lewitt, Peter" sort="Lewitt, Peter" uniqKey="Lewitt P" first="Peter" last="Lewitt">Peter Lewitt</name>
<name sortKey="Schultz, Lonni R" sort="Schultz, Lonni R" uniqKey="Schultz L" first="Lonni R" last="Schultz">Lonni R. Schultz</name>
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<country name="États-Unis"><noRegion><name sortKey="Silbergleit, Alice K" sort="Silbergleit, Alice K" uniqKey="Silbergleit A" first="Alice K" last="Silbergleit">Alice K. Silbergleit</name>
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Movement Disorders (revue)

Comparison of dysphagia before and after deep brain stimulation in Parkinson's disease.

Comparison of dysphagia before and after deep brain stimulation in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.